Chemical Biology

Technical Information

• Catalog

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• FG winds issue 1

  Isolation of drug target protein ‐ Methotrexate
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• FG winds issue 3

  Isolation of drug target protein ‐ Bisindolylmaleimide
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• FG winds issue 4

  Isolation of drug target protein ‐ Vorinostat
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• FG winds issue 9

  Isolation of drug target protein – Biotinylated MTX
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• Purification of proteins binding FK506(Tacrolimus)

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• Purification of proteins binding Bisindolylmaleimide X

  This study is the collaboration with a pharmaceutical company.
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• Purification of target proteins for kinase inhibitor Bisindolylmaleimide Ⅷ

  This study is a cooperative research with Medical ProteoScope Co., Ltd./p>

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• Competition

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• Drug elution

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• Azide beads / Alkyne beads

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• Streptavidin / NeutrAvidin beads

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Papers

• Ayaka Ikemizu et al.(2024)

  Identification and Characterization of Synaptic Vesicle Membrane Protein VAT-1 Homolog as a New Catechin-Binding Protein
  Biol. Pharm. Bull. 47, 509–517 (2024)

• Kotaro Mori et al.(2024)

  Novel ability of diflubenzuron as an inhibitor of mitochondrial function
  Insect Biochemistry and Molecular Biology Volume 167, April 2024, 104088

• Takumi Ito et al.(2023)

  Protein degraders – from thalidomide to new PROTACs
  The Journal of Biochemistry, Volume 175, Issue 5, May 2024, Pages 507–519

• Takumi Ito et al.(2023)

  Protein degraders – from thalidomide to new PROTACs
  The Journal of Biochemistry, Volume 175, Issue 5, May 2024, Pages 507–519

• Shuhei Kanagaki et al.(2023)

  Activation of AMP-activated protein kinase (AMPK)
  iScience 26, 106293, April 21, 2023

• Satoshi Yamanaka et al.(2023)

  Lenalidomide derivatives and proteolysis-targeting chimeras for controlling neosubstrate degradation
  Nature Communications | (2023) 14:4683

• N. Kajitani and M. Okada-Tsuchioka et al.(2023)

  G protein-biased LPAR1 agonism of prototypic antidepressants: Implication in the identification of novel therapeutic target for depression
  Neuropsychopharmacology; https://doi.org/10.1038/s41386-023-01727-9

• Naoharu Takano et al.(2023)

  Azithromycin, a potent autophagy inhibitor for cancer therapy, perturbs cytoskeletal protein dynamics
  British Journal of Cancer volume 128, pages1838–1849 (2023)

• Xian-Yang Qin et al.(2023)

  Targeting transglutaminase 2 mediated exostosin glycosyltransferase 1 signaling in liver cancer stem cells with acyclic retinoid
  Cell Death & Disease volume 14, Article number: 358 (2023)

• Yamamoto et al.(2022)

  History of IMiDs and Protein Degradation as a Pharmacological Modality
  Protein Homeostasis in Drug Discovery: A Chemical Biology Perspective
  Chapter 8

• Muna Al-Habsi et al.(2022)

  Spermidine activates mitochondrial trifunctional protein and improves antitumor immunity in mice
  SCIENCE 28 Oct 2022 Vol 378, Issue 6618

• Miyata et al.(2022)

  Sulforaphane suppresses the activity of sterol regulatory element-binding proteins (SREBPs) by promoting SREBP precursor degradation
  Scientifc Reports (2022) 12:8715

• Yamada et al.(2022)

  Identification of RPL15 60S Ribosomal Protein as a Novel Topotecan Target Protein That Correlates with DAMP Secretion and Antitumor Immune Activation
  J Immunol July 1, 2022, 209 (1) 171-179

• GA Frere et al.(2022)

  Emerging mechanisms of targeted protein degradation by molecular glues
  Methods Cell Biol. 2022;169:1-26

• Imai et al.(2022)

  Salicylic acid directly binds to ribosomal protein S3 and suppresses CDK4 expression in colorectal cancer cells
  Biochemical and Biophysical Research Communications Volume 628, 5 November 2022, Pages 110-115

• Iizumi et al.(2022)

  Stabilization of CDK6 by ribosomal protein uS7, a target protein of the natural product fucoxanthinol
  COMMUNICATIONS BIOLOGY (2022) 5:564

• Ichikawa et al.(2022)

  Inhibition of adult T-cell leukemia cell proliferation by polymerized proanthocyanidin from blueberry leaves through JAK proteolysis
  Cancer Science. 2022;113:1406–1416

• Ikeda et al.(2022)

  Genistein regulates adipogenesis by blocking the function of adenine nucleotide translocase-2 in the mitochondria
  Bioscience, Biotechnology, and Biochemistry, Volume 86, Issue 2, February 2022, Pages 260–272

• Watanabe et al.(2022)

  A chemoproteoinformatics approach demonstrates that aspirin increases sensitivity to MEK inhibition by directly binding to RPS5
  PNAS Nexus, 2022, 1, 1–11

• Yamamoto et al.(2022)

  Discovery of CRBN as a target of thalidomide: a breakthrough for progress in the development of protein degraders
  Chem. Soc. Rev. 2022

• R. Kamihira et al. (2022)

  Preparation and Application of a Chemical Probe for Identifying the Targets of the Marine Cyclic Peptide Kapakahine A
  Molecules 2022, 27, 1072

• K. Kobayashi-Nakamura et al. (2022)

  Rhamnazin suppresses melanosome transport by promoting the ubiquitin-mediated proteasomal degradation of melanophilin
  Journal of Dermatological Science 105 (2022) 45–54

• Hirata et al.(2022)

  Sirtuin inhibition and neurite outgrowth effect as new biological activities for Areca catechu nut alkaloids
  Phytomedicine Plus 2 (2022) 100294

• Bellail et al.(2021)

  Ubiquitination and degradation of SUMO1 by small-molecule degraders extends survival of mice with patient-derived tumors
  SCIENCE TRANSLATIONAL MEDICINE 13 Oct 2021 Vol 13, Issue 615

• Hamoya et al.(2021)

  Artesunate inhibits intestinal tumorigenesis through inhibiting wnt signaling
  Carcinogenesis, 2021, Vol. 42, No. 1, 148–158

• Ito et al.(2021)

  Exploiting ubiquitin ligase cereblon as a target for small-molecule compounds in medicine and chemical biology
  Cell Chemical Biology 28, July 15, 2021

• Dormán et al.(2021)

  Target identification and polypharmacology of nutraceuticals
  Nutraceuticals (Second Edition) Efficacy, Safety and Toxicity 2021, Pages 315-343

• Miao-Miao Zhao et al.(2021)

  Berberine is an insulin secretagogue targeting the KCNH6 potassium channel
  NATURE COMMUNICATIONS(2021) 12:5616

• Watanabe et al.(2021)

  Rabdosianone I, a Bitter Diterpene from an Oriental Herb, Suppresses Thymidylate Synthase Expression by Directly Binding to ANT2 and PHB2
  Cancers 2021, 13, 982

• Y. Kabe et al. (2021)

  Glycyrrhizin derivatives suppress cancer chemoresistance by inhibiting progesterone receptor membrane component 1
  Cancers, 13, 3265 (2021)

• Nan Yagishita-Kyo et al. (2021)

  Testosterone interrupts binding of Neurexin and Neuroligin that are expressed in a highly socialized rodent, Octodon degus
  Biochemical and Biophysical Research Communications 551 (2021) 54

• T. Tsukahara et al. (2021)

  Adenine nucleotide translocase 2, a putative target protein for 2-carba cyclic phosphatidic acid in microglial cells
  Cellular Signalling 82 (2021) 109951

• Saito et al.(2021)

  α-Trifluoromethyl Chalcones as Potent Anticancer Agents for Androgen Receptor-Independent Prostate Cancer
  Molecules 2021, 26, 2812

• Takano et al.(2020)

  The Surprising Effect of Phenformin on Cutaneous Darkening and Characterization of Its Underlying Mechanism by a Forward Chemical Genetics Approach
  Int J Mol Sci. 2020 Feb 20;21(4):1451

• Asatsuma-Okumura et al.(2020)

  Molecular Mechanisms of the Teratogenic Effects of Thalidomide
  Pharmaceuticals 2020, 13, 95; doi:10.3390/ph13050095

• K. Fujita et al. (2020)

  Pesticide treatment reduces hydrophobic pollutant contamination in Cucurbita pepo through competitive binding to major latex-like proteins
  Environmental Pollution 266 (2020) 115179

• A. Iwabuchi et al. (2020)

  Factors regulating the differential uptake of persistent organic pollutants in cucurbits and non-cucurbits
  Journal of Plant Physiology 245 (2020) 153094

• T. Saito et al. (2020)

  Nobiletin and related polymethoxylated flavones bind to and inhibit the nuclear export factor Exportin-1 in NK leukemia cell line KHYG-1
  Biochemical and Biophysical Research Communications 521 (2020) 457

• H. Tsugawa et al. (2020)

  Short-chain fatty acids bind to apoptosisassociated speck-like protein to activate inflammasome complex to prevent Salmonella infection
  PLoS Biol, 2020 18(9):e3000813

• J. Cho et al. (2020)

  L-Arginine prevents cereblon-mediated ubiquitination of glucokinase and stimulates glucose-6-phosphate production in pancreatic β-cells
  Communications Biology (2020) 3:497

• T. Ito et al. (2020)

  Molecular mechanisms of thalidomide and its derivatives
  Proc. Jpn. Acad., Ser. B 96 (2020)

• Y. Kabe et al. (2020)

  Annexin A1 accounts for an anti-inflammatory binding target of sesamin metabolites
  npj Science of Food (2020) 4

• J. Cho et al. (2020)

  UGGT1 retains proinsulin in the endoplasmic reticulum in an arginine dependent manner
  Biochemical and Biophysical Research Communications 527 (2020) 668

• T. Furukawa et al (2020)

  Dioctatin Activates ClpP to Degrade Mitochondrial Components and Inhibits Aflatoxin Production
  Cell Chemical Biology 27 (2020) 1396

• Wu et al.(2019)

  Anti-Inflammatory and Anticancer Properties of Bioactive Compounds from Sesamum indicum L.—A Review
  Molecules 2019, 24, 4426

• Kurata et al.(2019)

  Food-Derived Compounds Apigenin and Luteolin Modulate mRNA Splicing of Introns with Weak Splice Sites
  iScience 22, 336–352, December 20, 2019

• Yamada et al.(2019)

  Effect of fatty acids on melanogenesis and tumor cell growth in melanoma cells
  Journal of Lipid Research Volume 60, (2019) 1491

• Raymond Wu et al.(2019)

  Baicalein targets GTPase-mediated autophagy to eliminate liver tumor initiating stem cell-like cells resistant to mTORC1 inhibition
  Hepatology. 2018 November ; 68(5): 1726–1740

• J. Goto et al. (2019)

  Uptake mechanisms of polychlorinated biphenyls in Cucurbita pepo via xylem sap containing major latex-like proteins
  Environ. Exp. Bot., 162, 399(2019)

• Y. Yoshioka et al. (2019)

  Glabridin inhibits dexamethasone-induced muscle atrophy
  Arch. Biochem. Biophys., 664, 157(2019)