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Hiroyuki Mizuguchi et al.(2024)
Structure-activity relationship studies of pyrogallol as a calcineurin/NFAT signaling suppressor
Journal of Pharmacological Sciences 155 (2024) 140–147
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Makoto Shirakawa et al.(2024)
Rapamycin and Starvation Mitigate Indomethacin-Induced Intestinal Damage through Preservation of Lysosomal Vacuolar ATPase Integrity
J Pharmacol Exp Ther 390:108–115, July 2024
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Manami Kodaka et al.(2024)
Identification of a novel target of sulforaphane: Sulforaphane binds to acyl-protein thioesterase 2 (APT2) and attenuates its palmitoylation
Biochemical and Biophysical Research Communications 726 (2024) 150244
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Misaki Kabasawa et al.(2024)
Plakevulin A induces apoptosis and suppresses IL-6-induced STAT3 activation in HL60 cells
Bioorganic & Medicinal Chemistry Letters Volume 110, 15 September 2024, 129886
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Ayaka Ikemizu et al.(2024)
Identification and Characterization of Synaptic Vesicle Membrane Protein VAT-1 Homolog as a New Catechin-Binding Protein
Biol. Pharm. Bull. 47, 509–517 (2024)
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Masaki Shoji et al.(2024)
Bakuchiol targets mitochondrial proteins, prohibitins and voltage-dependent anion channels: new insights into developing anti-viral agents
J. Biol. Chem. (2024) 300(2) 105632
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Kotaro Mori et al.(2024)
Novel ability of diflubenzuron as an inhibitor of mitochondrial function
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Takumi Ito et al.(2023)
Protein degraders – from thalidomide to new PROTACs
The Journal of Biochemistry, Volume 175, Issue 5, May 2024, Pages 507–519
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Takumi Ito et al.(2023)
Protein degraders – from thalidomide to new PROTACs
The Journal of Biochemistry, Volume 175, Issue 5, May 2024, Pages 507–519
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Shuhei Kanagaki et al.(2023)
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Lenalidomide derivatives and proteolysis-targeting chimeras for controlling neosubstrate degradation
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N. Kajitani and M. Okada-Tsuchioka et al.(2023)
G protein-biased LPAR1 agonism of prototypic antidepressants: Implication in the identification of novel therapeutic target for depression
Neuropsychopharmacology; https://doi.org/10.1038/s41386-023-01727-9
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Naoharu Takano et al.(2023)
Azithromycin, a potent autophagy inhibitor for cancer therapy, perturbs cytoskeletal protein dynamics
British Journal of Cancer volume 128, pages1838–1849 (2023)
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Xian-Yang Qin et al.(2023)
Targeting transglutaminase 2 mediated exostosin glycosyltransferase 1 signaling in liver cancer stem cells with acyclic retinoid
Cell Death & Disease volume 14, Article number: 358 (2023)
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History of IMiDs and Protein Degradation as a Pharmacological Modality
Protein Homeostasis in Drug Discovery: A Chemical Biology Perspective
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Spermidine activates mitochondrial trifunctional protein and improves antitumor immunity in mice
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Sulforaphane suppresses the activity of sterol regulatory element-binding proteins (SREBPs) by promoting SREBP precursor degradation
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Identification of RPL15 60S Ribosomal Protein as a Novel Topotecan Target Protein That Correlates with DAMP Secretion and Antitumor Immune Activation
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Salicylic acid directly binds to ribosomal protein S3 and suppresses CDK4 expression in colorectal cancer cells
Biochemical and Biophysical Research Communications Volume 628, 5 November 2022, Pages 110-115
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Inhibition of adult T-cell leukemia cell proliferation by polymerized proanthocyanidin from blueberry leaves through JAK proteolysis
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Stabilization of CDK6 by ribosomal protein uS7, a target protein of the natural product fucoxanthinol
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Sirtuin inhibition and neurite outgrowth effect as new biological activities for Areca catechu nut alkaloids
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Rhamnazin suppresses melanosome transport by promoting the ubiquitin-mediated proteasomal degradation of melanophilin
Journal of Dermatological Science 105 (2022) 45–54
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Exploiting ubiquitin ligase cereblon as a target for small-molecule compounds in medicine and chemical biology
Cell Chemical Biology 28, July 15, 2021
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Artesunate inhibits intestinal tumorigenesis through inhibiting wnt signaling
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Ubiquitination and degradation of SUMO1 by small-molecule degraders extends survival of mice with patient-derived tumors
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Miao-Miao Zhao et al.(2021)
Berberine is an insulin secretagogue targeting the KCNH6 potassium channel
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Testosterone interrupts binding of Neurexin and Neuroligin that are expressed in a highly socialized rodent, Octodon degus
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Adenine nucleotide translocase 2, a putative target protein for 2-carba cyclic phosphatidic acid in microglial cells
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The Surprising Effect of Phenformin on Cutaneous Darkening and Characterization of Its Underlying Mechanism by a Forward Chemical Genetics Approach
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Molecular Mechanisms of the Teratogenic Effects of Thalidomide
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Dioctatin Activates ClpP to Degrade Mitochondrial Components and Inhibits Aflatoxin Production
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UGGT1 retains proinsulin in the endoplasmic reticulum in an arginine dependent manner
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Annexin A1 accounts for an anti-inflammatory binding target of sesamin metabolites
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L-Arginine prevents cereblon-mediated ubiquitination of glucokinase and stimulates glucose-6-phosphate production in pancreatic β-cells
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Pesticide treatment reduces hydrophobic pollutant contamination in Cucurbita pepo through competitive binding to major latex-like proteins
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Nobiletin and related polymethoxylated flavones bind to and inhibit the nuclear export factor Exportin-1 in NK leukemia cell line KHYG-1
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Anti-Inflammatory and Anticancer Properties of Bioactive Compounds from Sesamum indicum L.—A Review
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Glabridin inhibits dexamethasone-induced muscle atrophy
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