NH₂ beads

技術情報

• FG beadsカタログ

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• 受託サービス詳細資料

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• FG WAVE 1

  インタビュー ‐東京医科大学　半田宏先生
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• FG WAVE 6

  ユーザー研究内容紹介 ‐慶應義塾大学　加部泰明先生
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• FG WAVE 7

  インタビュー ‐九州大学　清水邦義先生
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論文

• Ayaka Ikemizu et al.(2024)

  Identification and Characterization of Synaptic Vesicle Membrane Protein VAT-1 Homolog as a New Catechin-Binding Protein
  Biol. Pharm. Bull. 47, 509–517 (2024)

• Satoshi Yamanaka et al.(2023)

  Lenalidomide derivatives and proteolysis-targeting chimeras for controlling neosubstrate degradation
  Nature Communications | (2023) 14:4683

• Sharma et al.(2022)

  Smartphone-based On-chip Homogenous Sensing by Analysis of Dynamics of Oscillating Polystyrene Particles under Dielectrophoretic Forces
  Sensors and Materials, Vol. 34, No. 6 (2022) 2089–2104

• Yamamoto et al.(2022)

  Discovery of CRBN as a target of thalidomide: a breakthrough for progress in the development of protein degraders
  Chem. Soc. Rev. 2022

• Hirata et al.(2022)

  Sirtuin inhibition and neurite outgrowth effect as new biological activities for Areca catechu nut alkaloids
  Phytomedicine Plus 2 (2022) 100294

• Ito et al.(2021)

  Exploiting ubiquitin ligase cereblon as a target for small-molecule compounds in medicine and chemical biology
  Cell Chemical Biology 28, July 15, 2021

• Hamoya et al.(2021)

  Artesunate inhibits intestinal tumorigenesis through inhibiting wnt signaling
  Carcinogenesis, 2021, Vol. 42, No. 1, 148–158

• Y. Kabe et al. (2021)

  Glycyrrhizin derivatives suppress cancer chemoresistance by inhibiting progesterone receptor membrane component 1
  Cancers, 13, 3265 (2021)

• Asatsuma-Okumura et al.(2020)

  Molecular Mechanisms of the Teratogenic Effects of Thalidomide
  Pharmaceuticals 2020, 13, 95; doi:10.3390/ph13050095

• Meguro et al.(2020)

  Pex3 confines pexophagy receptor activity of Atg36 to peroxisomes by regulating Hrr25-mediated phosphorylation and proteasomal degradation
  J. Biol. Chem. (2020) 295(48) 16292–16298

• Mochida et al.(2020)

  Super-assembly of ER-phagy receptor Atg40 induces local ER remodeling at contacts with forming autophagosomal membranes
  NATURE COMMUNICATIONS (2020) 11:3306

• T. Ito et al. (2020)

  Molecular mechanisms of thalidomide and its derivatives
  Proc. Jpn. Acad., Ser. B 96 (2020)

• Y. Kabe et al. (2020)

  Annexin A1 accounts for an anti-inflammatory binding target of sesamin metabolites
  npj Science of Food (2020) 4

• H. Tsugawa et al. (2020)

  Short-chain fatty acids bind to apoptosisassociated speck-like protein to activate inflammasome complex to prevent Salmonella infection
  PLoS Biol, 2020 18(9):e3000813

• M. Tera el al. (2019)

  Identification of a binding protein for sesamin and characterization of its roles in plant growth

  Scientific Reports, 9, 8631(2019)

• T. Asatsuma-Okumura el al. (2019)

  Molecular mechanisms of cereblon-based drugs
  Pharmacology & Therapeutics, 202, 132(2019)

• Yamada et al.(2019)

  Effect of fatty acids on melanogenesis and tumor cell growth in melanoma cells
  Journal of Lipid Research Volume 60, (2019) 1491

• H. Tan et al. (2019)

  Ursolic Acid Isolated from the Leaves of Loquat ( Eriobotrya japonica) Inhibited Osteoclast Differentiation through Targeting Exportin 5
  J. Agric. Food Chem., 67, 3333(2019)

• Raymond Wu et al.(2019)

  Baicalein targets GTPase-mediated autophagy to eliminate liver tumor initiating stem cell-like cells resistant to mTORC1 inhibition
  Hepatology. 2018 November ; 68(5): 1726–1740

• Li et al.(2018)

  IMiD compounds affect CD34+ cell fate and maturation via CRBN-induced IKZF1 degradation
  Blood Adv (2018) 2 (5): 492–504

• Y. Aono et al. (2018)

  Sulindac sulfone inhibits the mTORC1 pathway in colon cancer cells by directly targeting voltage-dependent anion channel 1 and 2
  Biochem. Biophys. Res. Commun., 505, 1203 (2018).

• Suzuki et al.(2018)

  Development of a fluorescent peptide for the highly sensitive and selective detection of oxytocin
  Sensors and Actuators B 254 (2018) 321–328

• Kabe et al.(2018)

  Function and structural regulation of the carbon monoxide (CO) responsive membrane protein PGRMC1
  J. Clin. Biochem. Nutr. 63 (2018) 12–17

• SR Kristensen et al. (2018) [ExoCounter]

  Blu-ray beyond music and movies—novel approach to diagnostics measuring specific extracellular vesicles
  Journal of Laboratory and Precision Medicine 84 (2018) 3

• T. mori et al. (2018)

  Structural basis of thalidomide enantiomer binding to cereblon
  Scientific Reports, 8, 1294 (2018).

• Fuchs et al.(2017)

  Immunomodulatory drugs and their therapeutic effect in hematological malignancies through cereblon
  Hematol Med Oncol, 2017 Volume 2(3): 1-8

• Keane K.Y. Lai et al.(2017)

  Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via Wnt Signaling and Stabilization of Low Density Lipoprotein Receptor-related Proteins 5 and 6
  Gastroenterology. 2017 May ; 152(6): 1477–1491

• Y. Nishiya et al. (2017)

  A new efficient method of generating photoaffinity beads for drug target identification
  Bioorg. Med. Chem. Lett., 27, 834 (2017).

• M. Boccitto et al. (2017)

  The Neuroprotective Marine Compound Psammaplysene A Binds the RNA-Binding Protein HNRNPK
  Mar. Drugs, 15, 246 (2017).

• Nugyen et al.(2016)

  Glutamine triggers acetylation-dependent degradation of glutamine synthetase via the thalidomide receptor cereblon
  Mol Cell. 2016 March 17; 61(6): 809–820

• Y. kabe et al. (2016)

  Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance
  Nature Communications, 7:11030 (2016).

• Kawakami et al.(2015)

  DIVERSE System: De Novo Creation of Peptide Tags for Non-enzymatic Covalent Labeling by In Vitro Evolution for Protein Imaging Inside Living Cells
  Chemistry & Biology 22 (2015) 1671–1679

• Y. Suzuki, A. Kuno, Y. Chiba. (2015)

  Development of fluorescent probes for “On-Off” switching baseddetection of lectin?saccharide interactions.
  Sens. Actuators B., 220, 389 (2015).

• P. P. Chamberlain et al. (2014)

  Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs
  Nat. Struct. Mol. Biol., 21, 803 (2014).

• A. Perez-Perarnau et al. (2014)

  A Trifluorinated Thiazoline Scaffold Leading to Pro-apoptotic Agents Targeting Prohibitins
  Angew. Chem. Int. Ed., 53, 10150 (2014).

• Chang et al.(2014)

  Mechanism of immunomodulatory drugs’ action in the treatment of multiple myeloma
  Acta Biochimica et Biophysica Sinica, Volume 46, Issue 3, March 2014, Pages 240–253

• Umeda et al.(2013)

  PGJIFs, new mitochondrial PGJ2 target factors, regulate cell proliferation
  Journal of Biosciences and Medicines, 2013, 1, 11-15

• Uebi et al.（2013)

  Prohibitins, novel vitamin K2 target factors in osteoblast
  Journal of Biosciences and Medicines, 2013, 1, 1-4

• A. Ikeda-Boku et al. (2013)

  Protein fishing using magnetic nano-beads containing calmodulin site-specifically immobilized via an azido-group
  J. Biochem., DOI:10.1093 (2013).

• A Lopez-Girona et al.(2012)

  Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide
  Leukemia volume 26, pages2326–2335 (2012)

• T. Ito, H. Handa. (2012)

  Deciphering the mystery of thalidomide teratogenicity
  Congenital Anomalies, 52, 1 (2012)

• J. Liu et al. (2012)

  Target proteins of ganoderic acid DM provides clues to various pharmacological mechanisms
  Scientific Reports, 2, 905 (2012).

• S. Sakamoto et al. (2012)

  Tools and methodologies capable of isolating and identifying a target molecule for a bioactive compound.
  Bioorg. Med. Chem., 20, 1990 (2012).

• N. Maekawa et al. (2011)

  High-performance affinity purification for identification of 15-deoxy-D12,14-PGJ2 interacting factors using magnetic nanobeads
  Biomed. Chromatogr., 25, 466 (2011).

• T. Ito, H. Ando, H. Handa. (2011)

  Teratogenic effects of thalidomide:molecular mechanisms
  Cell. Mol. Life Sci., 68,1569 (2011).

• T. Ito et al. (2010)

  Identification of a Primary Target of Thalidomide Teratogenicity
  Science, 327, 1345 (2010).

• K. Kume et al. (2010)

  Role of N-end rule ubiquitin ligases UBR1 and UBR2 inregulating the leucine-mTOR signaling pathway
  Genes Cells, 15, 339 (2010).

• S. Sakamoto et al. (2009)

  Development and Application of High-Performance Affinity Beads: Toward Chemical Biology and Drug Discovery.
  Chem. Rec., 9, 66 (2009).

• M. Azuma et al. (2008)

  Adenine nucleotide translocator transports haem precursors into mitochondria
  PLOS ONE, 3, e3070 (2008).

• Y. Kabe et al. (2006)

  Porphyrin accumulation in mitochondria is mediated by 2-oxoglutarate carrier
  J. Biol. Chem., 281, 31729 (2006).