{"id":16,"date":"2022-05-09T13:57:12","date_gmt":"2022-05-09T04:57:12","guid":{"rendered":"https:\/\/www.fgb.tamagawa-seiki.com\/english\/?page_id=16"},"modified":"2022-10-04T15:40:19","modified_gmt":"2022-10-04T06:40:19","slug":"chemical_biology","status":"publish","type":"page","link":"https:\/\/fgb.tamagawa-seiki.com\/english\/selection\/chemical_biology","title":{"rendered":"Chemical Biology"},"content":{"rendered":"<section class=\"question\">\n<div class=\"wrapper\">\n<p class=\"section-min\">Using the &#8220;chemical pull-down method,&#8221; which is a method for purifying target proteins using FG beads immobilized with a drug as a ligand, we analyze the functions and reaction mechanisms of molecules in vivo at the molecular level. FG beads are best at chemical biology because they can immobilize various kinds of compounds and have very little non-specific adsorption.<\/p>\n<h2 class=\"tit-cmn03\"><span class=\"ex\">STEP 01<\/span>Select a Purification Method<\/h2>\n<h3 class=\"tit\">Do you know the structure-activity relationship of compounds?<\/h3>\n<div class=\"all-area\">\n<div id=\"tabnavi\">\n<ul class=\"tab-area\">\n<li id=\"tab1\" class=\"select float-l\">Yes<\/li>\n<li id=\"tab2\" class=\"float-r\">No<\/li>\n<\/ul><\/div>\n<p>  <!--  tab1 start --> <\/p>\n<div class=\"content-area\">\n<h3 class=\"tit-cmn04\">The active site of the compound is clear<\/h3>\n<p>The site &#8220;1&#8221; and site &#8220;2&#8221; of the compound involve to the activity and are inactivated by immobilization on FG beads, so immobilization at the site &#8220;3&#8221; is required.<\/p>\n<p>    <img src=\"https:\/\/fgb.tamagawa-seiki.com\/english\/wp-content\/themes\/original\/images\/chemical_biology-images\/ill01.gif\" alt=\"The active site of the compound is clear.\" class=\"img-center mb30\"><\/p>\n<h4 class=\"tit-cmn05\">Direct method<\/h4>\n<p>After immobilizing the compound (drug) on the FG beads, the target protein is recovered (bound).<\/p>\n<p>    <img src=\"https:\/\/fgb.tamagawa-seiki.com\/english\/wp-content\/themes\/original\/images\/chemical_biology-images\/ill02.gif\" alt=\"Direct method\" class=\"sp-none mb30 img-center\"><\/p>\n<ul class=\"sp-only ill-list01\">\n<li><img src=\"https:\/\/fgb.tamagawa-seiki.com\/english\/wp-content\/themes\/original\/images\/chemical_biology-images\/sp01.gif\" alt=\"Direct method\" class=\"mb30 img-center\"><\/li>\n<li><img src=\"https:\/\/fgb.tamagawa-seiki.com\/english\/wp-content\/themes\/original\/images\/chemical_biology-images\/sp02.gif\" alt=\"Direct method\" class=\"mb30 img-center\"><\/li>\n<li><img src=\"https:\/\/fgb.tamagawa-seiki.com\/english\/wp-content\/themes\/original\/images\/chemical_biology-images\/sp03.gif\" alt=\"Direct method\" class=\"mb30 img-center\"><\/li>\n<\/ul>\n<h4 class=\"tit-cmn05\">Indirect method<\/h4>\n<p>After binding the compound (drug) and the target protein, the complex of &#8220;compound + target protein&#8221; is recovered by FG beads. It is necessary to introduce azide, alkyne, biotin, tag, etc.<\/p>\n<p>    <img src=\"https:\/\/fgb.tamagawa-seiki.com\/english\/wp-content\/themes\/original\/images\/chemical_biology-images\/ill03.gif\" alt=\"Indirect method\" class=\"sp-none mb30 img-center\"><\/p>\n<ul class=\"sp-only ill-list01\">\n<li><img src=\"https:\/\/fgb.tamagawa-seiki.com\/english\/wp-content\/themes\/original\/images\/chemical_biology-images\/sp04.gif\" alt=\"Indirect method\" class=\"mb30 img-center\"><\/li>\n<li><img src=\"https:\/\/fgb.tamagawa-seiki.com\/english\/wp-content\/themes\/original\/images\/chemical_biology-images\/sp05.gif\" alt=\"Indirect method\" class=\"mb30 img-center\"><\/li>\n<li><img src=\"https:\/\/fgb.tamagawa-seiki.com\/english\/wp-content\/themes\/original\/images\/chemical_biology-images\/sp06.gif\" alt=\"Indirect method\" class=\"mb30 img-center\"><\/li>\n<\/ul><\/div>\n<p>  <!--  tab2 start --> <\/p>\n<div class=\"content-area hide\" style=\"display: none;\">\n<h3 class=\"tit-cmn04\">The active site of the compound is unknown<\/h3>\n<p>If it is unclear which site of the compound contributes to the activity, each site should be immobilized on FG beads. It is desirable to prepare FG beads according to the site to be immobilized. In the following cases, it is desirable to prepare three types.<\/p>\n<p>    <img src=\"https:\/\/fgb.tamagawa-seiki.com\/english\/wp-content\/themes\/original\/images\/chemical_biology-images\/ill04.gif\" alt=\"The active site of the compound is unknown\" class=\"img-center mb30\"><\/p>\n<h4 class=\"tit-cmn05\">Direct method<\/h4>\n<p>After immobilizing the compound (drug) on the FG beads, the target protein is recovered (bound).<\/p>\n<p>    <img src=\"https:\/\/fgb.tamagawa-seiki.com\/english\/wp-content\/themes\/original\/images\/chemical_biology-images\/ill02.gif\" alt=\"Direct method\" class=\"sp-none mb30 img-center\"><\/p>\n<ul class=\"sp-only ill-list01\">\n<li><img src=\"https:\/\/fgb.tamagawa-seiki.com\/english\/wp-content\/themes\/original\/images\/chemical_biology-images\/sp01.gif\" alt=\"Direct method\" class=\"mb30 img-center\"><\/li>\n<li><img src=\"https:\/\/fgb.tamagawa-seiki.com\/english\/wp-content\/themes\/original\/images\/chemical_biology-images\/sp02.gif\" alt=\"Direct method\" class=\"mb30 img-center\"><\/li>\n<li><img src=\"https:\/\/fgb.tamagawa-seiki.com\/english\/wp-content\/themes\/original\/images\/chemical_biology-images\/sp03.gif\" alt=\"Direct method\" class=\"mb30 img-center\"><\/li>\n<\/ul><\/div>\n<p><!-- \/tab area end --><\/div>\n<\/div>\n<\/section>\n<section>\n<div class=\"wrapper\">\n<h2 class=\"tit-cmn03\"><span class=\"ex\">STEP 02<\/span>Select the FG beads to Use<\/h2>\n<p class=\"txt-min sp-only mb10\">\u203bPlease scroll horizontally.<\/p>\n<div class=\"scroll-box mb20\">\n<table class=\"choice table-link\">\n<tr>\n<th>Difficulty of immobilization<\/th>\n<th class=\"cel-blue\"><\/th>\n<th class=\"cel-blue\">Functional group at the site of immobilization<br \/>(compound side)<\/th>\n<th class=\"cel-pink\">FG beads to use<\/th>\n<\/tr>\n<tr>\n<td class=\"cel-white\">Low<\/td>\n<td rowspan=\"6\" class=\"cel-blue02\">Direct method<\/td>\n<td>NH<sub>2<\/sub><\/td>\n<td class=\"cel-pink02\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/products\/nhs_beads\">NHS beads<\/a><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/products\/cooh_beads\">COOH beads<\/a><\/td>\n<\/tr>\n<tr>\n<td rowspan=\"6\" class=\"cel-white arrow\"><\/td>\n<td>COOH<\/td>\n<td class=\"cel-pink02\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/products\/nh2_beads\">NH<sub>2<\/sub> beads<\/a><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/products\/oh_beads\">OH beads<\/a><\/td>\n<\/tr>\n<tr>\n<td>Azide<\/td>\n<td class=\"cel-pink02\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/products\/alkyne_beads\">Alkyne beads<\/a><\/td>\n<\/tr>\n<tr>\n<td>Alkyne (Ethynyl)<\/td>\n<td class=\"cel-pink02\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/products\/azide_beads\">Azide beads<\/a><\/td>\n<\/tr>\n<tr>\n<td>OH(Phenolic)<\/td>\n<td class=\"cel-pink02\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/products\/epoxy_beads\">Epoxy beads<\/a><\/td>\n<\/tr>\n<tr>\n<td>OH<\/td>\n<td class=\"cel-pink02\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/products\/cooh_beads\">COOH beads<\/a><\/td>\n<\/tr>\n<tr>\n<td rowspan=\"2\" class=\"cel-blue02\">Indirect method<\/td>\n<td>Azide<\/td>\n<td class=\"cel-pink02\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/products\/alkyne_beads\">Alkyne beads<\/a><\/td>\n<\/tr>\n<tr>\n<td class=\"cel-white\">High<\/td>\n<td>Alkyne (Ethynyl)<\/td>\n<td class=\"cel-pink02\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/products\/azide_beads\">Azide beads<\/a><\/td>\n<\/tr>\n<\/table><\/div>\n<ul class=\"li-cmn03 section-min\">\n<li>If the compound does not have the above functional groups, it is necessary to introduce (synthesize) a valid functional group.<\/li>\n<li>The indirect method is theoretically feasible, but we have no track record and no protocol.<\/li>\n<\/ul>\n<div class=\"point-box\">\n<ul>\n<li class=\"ill01\">\n      <img src=\"https:\/\/fgb.tamagawa-seiki.com\/english\/wp-content\/themes\/original\/images\/chemical_biology-images\/image01.png\" alt=\"mascot\">\n    <\/li>\n<li class=\"txt\">\n<h3>Point 1<\/h3>\n<table border=\"2\" bordercolor=\"white\">\n   \u3000 <\/p>\n<tr>\n     \u3000 <\/p>\n<td valign=\"top\" width=\"80%\">\n<p>Experiments will not work if the amount of compound immobilization is high or low. First of all, it is important to carry out experiments with the amount of preparation under 4 conditions and find the optimum immobilization conditions for each compound.<\/p>\n<\/td>\n<p>     \u3000 <\/p>\n<td><img src=\"https:\/\/fgb.tamagawa-seiki.com\/english\/wp-content\/themes\/original\/images\/chemical_biology-images\/image02.gif\" alt=\"figure\"><\/td>\n<p>  \u3000  <\/tr>\n<p>\u3000\u3000  <\/table>\n<h3>Point 2<\/h3>\n<p class=\"link01 mb30\">By performing <a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/wp-content\/uploads\/2022\/06\/Competition.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">competitive inhibition<\/a> and <a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/wp-content\/uploads\/2022\/06\/Drug_elution.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">drug elution<\/a>, it is also possible to narrow down the binding protein band and evaluate the specificity of the binding protein.<\/p>\n<\/li>\n<\/ul><\/div>\n<\/div>\n<\/section>\n<section>\n<div class=\"wrapper\">\n  <div class=\"tab-wrap fade tab-design01\">\n    <ul class=\"tab-nav tab-ul01\">\n      <li class=\"tab-btn show\"><span>Protocol<\/span><\/li>\n      <li class=\"tab-btn\"><span>FAQ<\/span><\/li>\n      <li class=\"tab-btn\"><span>Papers \/ Technical Information<\/span><\/li>\n      <li class=\"tab-btn\"><span>Related Products<\/span><\/li>\n    <\/ul>\n    <div class=\"tab-contents show tab-txt01\">\n  <ul>\n  \n  <li><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/protocol\/screening-by-using-ligand-immobilized-beads\">Screening by using ligand immobilized beads<\/a><\/li>\n  \n  <li><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/protocol\/immobilization-of-ligands-compounds-with-phenol-groups-or-nh2-groups-on-epoxy-beads\">Immobilization of ligands (compounds with phenol groups or NH<sub>2<\/sub> groups) on epoxy beads<\/a><\/li>\n  \n  <li><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/protocol\/immobilization-of-ligands-compounds-with-phenol-groups-or-nh2-groups-on-epoxy-beads-small-scale-method\">Immobilization of ligands (compounds with phenol groups or NH<sub>2<\/sub> groups) on epoxy beads (Small scale method)<\/a><\/li>\n  \n  <li><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/protocol\/immobilization-of-ligands-carboxylic-compounds-on-oh-beads\">Immobilization of ligands (carboxylic compounds) on OH beads<\/a><\/li>\n  \n  <li><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/protocol\/immobilization-of-ligands-carboxylic-compounds-on-oh-beads-2\">Immobilization of ligands (carboxylic compounds) on OH beads (Small scale method)<\/a><\/li>\n  \n  <li><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/protocol\/immobilization-of-ligands-carboxylic-compounds-on-nh2-beads\">Immobilization of ligands (carboxylic compounds) on NH<sub>2<\/sub> beads<\/a><\/li>\n  \n  <li><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/protocol\/immobilization-of-ligands-carboxylic-compounds-on-nh2-beads-small-scale-method\">Immobilization of ligands (carboxylic compounds) on NH<sub>2<\/sub> beads (Small scale method)<\/a><\/li>\n  \n  <li><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/protocol\/immobilization-of-ligands-compounds-with-nh2-groups-on-cooh-beads\">Immobilization of ligands (compounds with NH<sub>2<\/sub> groups) on COOH beads<\/a><\/li>\n  \n  <li><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/protocol\/immobilization-of-ligands-compounds-with-nh2-groups-on-cooh-beads-small-scale-method\">Immobilization of ligands (compounds with NH<sub>2<\/sub> groups) on COOH beads (Small scale method)<\/a><\/li>\n  \n  <li><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/protocol\/competitive-inhibition\">Competitive inhibition<\/a><\/li>\n  \n  <li><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/protocol\/drug-elution\">Drug elution<\/a><\/li>\n  \n  <li><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/protocol\/nhs-beads%e3%81%b8%e3%81%aenh2%e3%83%aa%e3%82%ac%e3%83%b3%e3%83%89%e3%81%ae%e5%9b%ba%e5%ae%9a%e5%8c%96\">Immobilization of ligands (compounds with NH<sub>2<\/sub> groups) on NHS beads<\/a><\/li>\n  \n  <li><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/protocol\/immobilization-of-ligands-compounds-with-nh2-groups-on-nhs-beads-small-scale-method\">Immobilization of ligands (compounds with NH<sub>2<\/sub> groups) on NHS beads (Small scale method)<\/a><\/li>\n  \n  <li><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/protocol\/immobilization-of-ligands-compounds-with-oh-groups-on-cooh-beads\">Immobilization of ligands (compounds with OH groups) on COOH beads<\/a><\/li>\n  \n  <li><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/protocol\/mmobilization-of-biotinylated-molecule-on-streptavidin-beads-and-neutravidin-beads\">Immobilization of biotinylated molecule on Streptavidin beads and NeutrAvidin beads<\/a><\/li>\n  \n  <li><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/protocol\/immobilization-of-ligands-alkyne-structure-compounds-on-azide-beads-using-click-chemistry-reaction\">Immobilization of ligands (alkyne structure compounds) on azide beads using click chemistry reaction<\/a><\/li>\n  \n  <li><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/protocol\/immobilization-of-ligands-alkyne-structure-compounds-on-azide-beads-using-click-chemistry-reaction-small-scale-method\">Immobilization of ligands (alkyne structure compounds) on azide beads using click chemistry reaction (Small scale method)<\/a><\/li>\n  \n  <li><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/protocol\/immobilization-of-ligands-azide-structure-compounds-on-alkyne-beads-using-click-chemistry-reaction\">Immobilization of ligands (azide structure compounds) on alkyne beads using click chemistry reaction<\/a><\/li>\n  \n  <li><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/protocol\/immobilization-of-ligands-azide-structure-compounds-on-alkyne-beads-using-click-chemistry-reaction-small-scale-method\">Immobilization of ligands (azide structure compounds) on alkyne beads using click chemistry reaction (Small scale method)<\/a><\/li>\n  \n  <li><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/protocol\/quantifying-the-amount-of-ligand-immobilization-by-hplc-high-performance-liquid-chromatography\">Quantifying the amount of ligand immobilization by HPLC (High Performance Liquid Chromatography)<\/a><\/li>\n  \n  <li><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/protocol\/preparation-of-cell-extract-large-scale-method\">Preparation of cell extract (Large scale method)<\/a><\/li>\n  \n  <li><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/protocol\/preparation-of-cell-extract-small-scale-method\">Preparation of cell extract (Small scale method)<\/a><\/li>\n    <\/ul>\n\n    <\/div>\n    <div class=\"tab-contents tab-txt01\">\n  <ul>\n  \n  <li><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/faq\/please-tell-me-how-to-separate-fg-beads-magnetic-separation-and-centrifugation\">Please tell me how to separate FG beads (magnetic separation and centrifugation).<\/a><\/li>\n  \n  <li><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/faq\/screening\">Please tell me how to disperse FG beads (ultrasonic method and manual method).<\/a><\/li>\n  \n  <li><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/faq\/what-is-the-general-process-used-to-bind-ligands-to-the-beads\">What is the general process used to bind ligands to the beads?<\/a><\/li>\n  \n  <li><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/faq\/what-amount-of-the-beads-is-required\">What amount of the beads is required?<\/a><\/li>\n  \n  <li><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/faq\/what-are-the-important-points-when-designing-a-ligand\">What are the important points when designing a ligand?<\/a><\/li>\n  \n  <li><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/faq\/is-it-possible-to-bind-secondary-amines\">Is it possible to bind secondary amines?<\/a><\/li>\n  \n  <li><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/faq\/how-are-beads-stored-after-the-ligands-are-bound-to-them\">How are beads stored after the ligands are bound to them?<\/a><\/li>\n  \n  <li><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/faq\/are-there-any-methods-other-than-hplc-for-verifying-whether-or-not-ligand-binding-has-been-successful\">Are there any methods other than HPLC for verifying whether or not ligand binding has been successful?<\/a><\/li>\n  \n  <li><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/faq\/how-strong-is-the-affinity-for-the-proteins-that-are-affinity-purified\">How strong is the affinity for the proteins that are affinity purified?<\/a><\/li>\n  \n  <li><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/faq\/what-is-the-purification-efficiency\">What is the purification efficiency?<\/a><\/li>\n  \n  <li><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/faq\/what-is-the-optimal-bead-type-for-binding-peptides\">What is the optimal bead type for binding peptides?<\/a><\/li>\n  \n  <li><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/faq\/how-is-the-cell-extract-prepared\">How is the cell extract prepared?<\/a><\/li>\n  \n  <li><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/faq\/is-there-any-problem-with-using-frozen-stock-homogenate\">Is there any problem with using frozen stock homogenate?<\/a><\/li>\n  \n  <li><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/faq\/how-much-protein-supply-is-necessary\">How much protein supply is necessary?<\/a><\/li>\n  \n  <li><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/faq\/can-affinity-purification-be-used-with-membrane-proteins-such-as-gpcrs-and-ion-channels\">Can affinity purification be used with membrane proteins such as GPCRs and ion channels?<\/a><\/li>\n  \n  <li><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/faq\/is-this-because-the-background-level-high\">There are many background bands. how can i reduce it?<\/a><\/li>\n  \n  <li><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/faq\/what-should-be-done-when-a-large-number-of-bound-protein-bands-are-detected\">What should be done when a large number of bound protein bands are detected?<\/a><\/li>\n  \n  <li><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/faq\/is-it-necessary-to-use-the-recommended-buffer-as-the-binding-buffer\">Is it necessary to use the recommended buffer as the binding buffer?<\/a><\/li>\n  \n  <li><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/faq\/why-is-it-that-both-salt-elution-and-boil-elution-are-performed-for-elution\">Why is it that both salt elution and boil elution are performed for elution?<\/a><\/li>\n  \n  <li><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/faq\/does-it-happen-that-the-band-of-bound-protein-becomes-thin-when-the-concentration-of-ligand-is-increased\">Does it happen that the band of bound protein becomes thin when the concentration of ligand is increased?<\/a><\/li>\n  \n  <li><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/faq\/why-cant-i-see-any-bands-of-bound-proteins\">Why can&#8217;t I see any bands of bound proteins?<\/a><\/li>\n  \n  <li><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/faq\/how-long-is-the-stable-period-of-the-ligand-immobilized-beads\">How long is the stable period of the ligand-immobilized beads?<\/a><\/li>\n  \n  <li><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/faq\/is-the-optimal-binding-reaction-time-of-4-hours\">Is the optimal binding reaction time of 4 hours?<\/a><\/li>\n  \n  <li><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/faq\/i-want-to-analyze-bound-proteins-with-ms-but-what-should-i-do-if-the-target-protein-band-is-thin\">I want to analyze bound proteins with MS, but what should I do if the target protein band is thin?<\/a><\/li>\n  \n  <li><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/faq\/how-much-protein-can-be-analyzed-by-ms\">How much protein can be analyzed by MS?<\/a><\/li>\n    <\/ul>\n\n    <\/div>\n\t\t\n<div class=\"tab-contents tab-technology\">\n      <h3>Technical Information<\/h3>\n  <ul class=\"mb30\">\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/catalog\">Catalog<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/my.ebook5.net\/tamagawa-seiki\/nanojiseiE\/\" target=\"_blank\" rel=\"noopener noreferrer\"><span class=\"link-e\">Learn More\u2192<\/span><\/a><\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/fg-winds-issue-1\">FG winds issue 1<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p>Isolation of drug target protein \u2010 Methotrexate<br \/>\n<a href=\"https:\/\/www.fgb.tamagawa-seiki.com\/english\/wp-content\/uploads\/2022\/06\/FG_winds_issue1.pdf\" target=\"_blank\" rel=\"noopener noreferrer\"><span class=\"link-pdf\">Learn More\u2192<\/span><\/a><\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/fg-winds-issue-3\">FG winds issue 3<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p>Isolation of drug target protein \u2010 Bisindolylmaleimide<br \/>\n<a href=\"https:\/\/www.fgb.tamagawa-seiki.com\/english\/wp-content\/uploads\/2022\/06\/FG_winds_issue3.pdf\" target=\"_blank\" rel=\"noopener noreferrer\"><span class=\"link-pdf\">Learn More\u2192<\/span><\/a><\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/fg-winds-issue-4\">FG winds issue 4<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p>Isolation of drug target protein \u2010 Vorinostat<br \/>\n<a href=\"https:\/\/www.fgb.tamagawa-seiki.com\/english\/wp-content\/uploads\/2022\/06\/FG_winds_issue4.pdf\" target=\"_blank\" rel=\"noopener noreferrer\"><span class=\"link-pdf\">Learn More\u2192<\/span><\/a><\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/fg-winds-issue-9\">FG winds issue 9<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p>Isolation of drug target protein \u2013 Biotinylated MTX<br \/>\n<a href=\"https:\/\/www.fgb.tamagawa-seiki.com\/english\/wp-content\/uploads\/2022\/06\/FG_winds_issue9.pdf\" target=\"_blank\" rel=\"noopener noreferrer\"><span class=\"link-pdf\">Learn More\u2192<\/span><\/a><\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/purification-of-proteins-binding-fk506tacrolimus\">Purification of proteins binding FK506(Tacrolimus)<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/www.fgb.tamagawa-seiki.com\/english\/wp-content\/uploads\/2022\/06\/ENG_FK506-1.pdf\" target=\"_blank\" rel=\"noopener noreferrer\"><span class=\"link-pdf\">Learn More\u2192<\/span><\/a><\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/purification-of-proteins-binding-bisindolylmaleimide-x\">Purification of proteins binding Bisindolylmaleimide X<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p>This study is the collaboration with a pharmaceutical company.<br \/>\n<a href=\"https:\/\/www.fgb.tamagawa-seiki.com\/english\/wp-content\/uploads\/2022\/06\/ENG_BisX-1.pdf\" target=\"_blank\" rel=\"noopener noreferrer\"><span class=\"link-pdf\">Learn More\u2192<\/span><\/a><\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/purification-of-target-proteins-for-kinase-inhibitor-bisindolylmaleimide-%e2%85%b7\">Purification of target proteins for kinase inhibitor Bisindolylmaleimide \u2167<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p>This study is a cooperative research with Medical ProteoScope Co., Ltd.\/p><\/p>\n<p><a href=\"https:\/\/www.fgb.tamagawa-seiki.com\/english\/wp-content\/uploads\/2022\/06\/Kinase_Bis8-1.pdf\" target=\"_blank\" rel=\"noopener noreferrer\"><span class=\"link-pdf\">Learn More\u2192<\/span><\/a><\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/competition\">Competition<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/www.fgb.tamagawa-seiki.com\/english\/wp-content\/uploads\/2022\/06\/Competition.pdf\" target=\"_blank\" rel=\"noopener noreferrer\"><span class=\"link-pdf\">Learn More\u2192<\/span><\/a><\/p>\n<p>&nbsp;<\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/drug-elution\">Drug elution<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/www.fgb.tamagawa-seiki.com\/english\/wp-content\/uploads\/2022\/06\/Drug_elution.pdf\" target=\"_blank\" rel=\"noopener noreferrer\"><span class=\"link-pdf\">Learn More\u2192<\/span><\/a><\/p>\n<p>&nbsp;<\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/azide-beads-alkyne-beads\">Azide beads \/ Alkyne beads<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/www.fgb.tamagawa-seiki.com\/english\/wp-content\/uploads\/2022\/06\/AzidebeadsAlkynebeads.pdf\" target=\"_blank\" rel=\"noopener noreferrer\"><span class=\"link-pdf\">Learn More\u2192<\/span><\/a><\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/streptavidin-beads\">Streptavidin \/ NeutrAvidin beads<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/www.fgb.tamagawa-seiki.com\/english\/wp-content\/uploads\/2022\/06\/SANA_beads.pdf\" target=\"_blank\" rel=\"noopener noreferrer\"><span class=\"link-pdf\">Learn More\u2192<\/span><\/a><\/p>\n\t\t<\/div>  \n\t<\/li>\n    <\/ul>\n        \n\n\n      <h3>Papers<\/h3>\n  <ul>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/hiroyuki-mizuguchi-et-al-2024\">Hiroyuki Mizuguchi et al.(2024)<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/doi.org\/10.1016\/j.jphs.2024.06.002\">Structure-activity relationship studies of pyrogallol as a calcineurin\/NFAT signaling suppressor<\/a><br \/>\nJournal of Pharmacological Sciences 155 (2024) 140\u2013147<\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/makoto-shirakawa-et-al-2024\">Makoto Shirakawa et al.(2024)<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/doi.org\/10.1124\/jpet.123.001981\">Rapamycin and Starvation Mitigate Indomethacin-Induced Intestinal Damage through Preservation of Lysosomal Vacuolar ATPase Integrity<\/a><br \/>\nJ Pharmacol Exp Ther 390:108\u2013115, July 2024<\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/manami-kodaka-et-al-2024\">Manami Kodaka et al.(2024)<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/doi.org\/10.1016\/j.bbrc.2024.150244\">Identification of a novel target of sulforaphane: Sulforaphane binds to acyl-protein thioesterase 2 (APT2) and attenuates its palmitoylation <\/a><br \/>\nBiochemical and Biophysical Research Communications 726 (2024) 150244<\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/ayaka-ikemizu-et-al-2024\">Ayaka Ikemizu et al.(2024)<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/doi.org\/10.1248\/bpb.b23-00830\">Identification and Characterization of Synaptic Vesicle Membrane Protein VAT-1 Homolog as a New Catechin-Binding Protein<\/a><br \/>\nBiol. Pharm. Bull. 47, 509\u2013517 (2024)<\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/misaki-kabasawa-et-al-2024\">Misaki Kabasawa et al.(2024)<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/doi.org\/10.1016\/j.bmcl.2024.129886\">Plakevulin A induces apoptosis and suppresses IL-6-induced STAT3 activation in HL60 cells<\/a><br \/>\nBioorganic &amp; Medicinal Chemistry Letters Volume 110, 15 September 2024, 129886<\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/kotaro-mori-et-al-2024\">Kotaro Mori et al.(2024)<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/doi.org\/10.1016\/j.ibmb.2024.104088\">Novel ability of diflubenzuron as an inhibitor of mitochondrial function<\/a><br \/>\nInsect Biochemistry and Molecular Biology Volume 167, April 2024, 104088<\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/kentaro-fujita-et-al-2023\">Kentaro Fujita et al.(2023)<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/doi.org\/10.1584\/jpestics.D23-014\">Major latex-like proteins show pH dependency in their binding to hydrophobic organic pollutants<\/a><br \/>\nJ. Pestic. Sci. 48(3), 71\u201377 (2023)<\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/takumi-ito-et-al-2023-2\">Takumi Ito et al.(2023)<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/doi.org\/10.1093\/jb\/mvad113\">Protein degraders &#8211; from thalidomide to new PROTACs<\/a><br \/>\nThe Journal of Biochemistry, Volume 175, Issue 5, May 2024, Pages 507\u2013519<\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/takumi-ito-et-al-2023\">Takumi Ito et al.(2023)<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/doi.org\/10.1093\/jb\/mvad113\">Protein degraders &#8211; from thalidomide to new PROTACs<\/a><br \/>\nThe Journal of Biochemistry, Volume 175, Issue 5, May 2024, Pages 507\u2013519<\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/shuhei-kanagaki-et-al-2023\">Shuhei Kanagaki et al.(2023)<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/doi.org\/10.1016\/j.isci.2023.106293\">Activation of AMP-activated protein kinase (AMPK)<\/a><br \/>\niScience 26, 106293, April 21, 2023<\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/satoshi-yamanaka-et-al-2023\">Satoshi Yamanaka et al.(2023)<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/doi.org\/10.1038\/s41467-023-40385-9\">Lenalidomide derivatives and proteolysis-targeting chimeras for controlling neosubstrate degradation<\/a><br \/>\nNature Communications | (2023) 14:4683<\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/n-kajitani-and-m-okada-tsuchioka-et-al-2023\">N. Kajitani and M. Okada-Tsuchioka et al.(2023)<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/www.nature.com\/articles\/s41386-023-01727-9\">G protein-biased LPAR1 agonism of prototypic antidepressants: Implication in the identification of novel therapeutic target for depression<\/a><br \/>\nNeuropsychopharmacology; https:\/\/doi.org\/10.1038\/s41386-023-01727-9<\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/naoharu-takano-et-al-2023\">Naoharu Takano et al.(2023)<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/www.nature.com\/articles\/s41416-023-02210-4\">Azithromycin, a potent autophagy inhibitor for cancer therapy, perturbs cytoskeletal protein dynamics<\/a><br \/>\nBritish Journal of Cancer volume 128, pages1838\u20131849 (2023)<\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/xian-yang-qin-et-al-2023\">Xian-Yang Qin et al.(2023)<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/www.nature.com\/articles\/s41419-023-05847-4\">Targeting transglutaminase 2 mediated exostosin glycosyltransferase 1 signaling in liver cancer stem cells with acyclic retinoid<\/a><br \/>\nCell Death &amp; Disease volume 14, Article number: 358 (2023)<\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/yamamoto-et-al-2022-2\">Yamamoto et al.(2022)<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/9781119774198.ch8\">History of IMiDs and Protein Degradation as a Pharmacological Modality<\/a><br \/>\nProtein Homeostasis in Drug Discovery: A Chemical Biology Perspective<br \/>\nChapter 8<\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/muna-al-habsi-et-al-2022\">Muna Al-Habsi et al.(2022)<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/www.science.org\/doi\/abs\/10.1126\/science.abj3510\" target=\"_blank\" rel=\"noopener noreferrer\">Spermidine activates mitochondrial trifunctional protein and improves antitumor immunity in mice<\/a><br \/>\nSCIENCE 28 Oct 2022 Vol 378, Issue 6618<\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/miyata-et-al-2022\">Miyata et al.(2022)<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/www.nature.com\/articles\/s41598-022-12347-6\" target=\"_blank\" rel=\"noopener noreferrer\">Sulforaphane suppresses the activity of sterol regulatory element-binding proteins (SREBPs) by promoting SREBP precursor degradation<\/a><br \/>\nScientifc Reports (2022) 12:8715<\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/yamada-et-al-2022\">Yamada et al.(2022)<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/www.jimmunol.org\/content\/209\/1\/171.abstract\" target=\"_blank\" rel=\"noopener noreferrer\">Identification of RPL15 60S Ribosomal Protein as a Novel Topotecan Target Protein That Correlates with DAMP Secretion and Antitumor Immune Activation<\/a><br \/>\nJ Immunol July 1, 2022, 209 (1) 171-179<\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/ga-frere-et-al-2022\">GA Frere et al.(2022)<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35623698\/\" target=\"_blank\" rel=\"noopener noreferrer\">Emerging mechanisms of targeted protein degradation by molecular glues<\/a><br \/>\nMethods Cell Biol. 2022;169:1-26<\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/imai-et-al-2022\">Imai et al.(2022)<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0006291X22012219\" target=\"_blank\" rel=\"noopener noreferrer\">Salicylic acid directly binds to ribosomal protein S3 and suppresses CDK4 expression in colorectal cancer cells<\/a><br \/>\nBiochemical and Biophysical Research Communications Volume 628, 5 November 2022, Pages 110-115<\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/iizumi-et-al-2022\">Iizumi et al.(2022)<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/www.nature.com\/articles\/s42003-022-03522-6\" target=\"_blank\" rel=\"noopener noreferrer\">Stabilization of CDK6 by ribosomal protein uS7, a target protein of the natural product fucoxanthinol<\/a><br \/>\nCOMMUNICATIONS BIOLOGY (2022) 5:564 <\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/ichikawa-et-al-2022\">Ichikawa et al.(2022)<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35100463\/\" target=\"_blank\" rel=\"noopener noreferrer\">Inhibition of adult T-cell leukemia cell proliferation by polymerized proanthocyanidin from blueberry leaves through JAK proteolysis<\/a><br \/>\nCancer Science. 2022;113:1406\u20131416<\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/ikeda-et-al-2022\">Ikeda et al.(2022)<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/academic.oup.com\/bbb\/article-abstract\/86\/2\/260\/6445991?login=false#no-access-message\" target=\"_blank\" rel=\"noopener noreferrer\">Genistein regulates adipogenesis by blocking the function of adenine nucleotide translocase-2 in the mitochondria<\/a><br \/>\nBioscience, Biotechnology, and Biochemistry, Volume 86, Issue 2, February 2022, Pages 260\u2013272<\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/watanabe-et-al-2022\">Watanabe et al.(2022)<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/academic.oup.com\/pnasnexus\/article\/1\/2\/pgac059\/6585680\" target=\"_blank\" rel=\"noopener noreferrer\">A chemoproteoinformatics approach demonstrates that aspirin increases sensitivity to MEK inhibition by directly binding to RPS5<\/a><br \/>\nPNAS Nexus, 2022, 1, 1\u201311<\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/yamamoto-et-al-2022\">Yamamoto et al.(2022)<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2022\/CS\/D2CS00116K\" target=\"_blank\" rel=\"noopener noreferrer\">Discovery of CRBN as a target of thalidomide: a breakthrough for progress in the development of protein degraders<\/a><br \/>\nChem. Soc. Rev. 2022<\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/r-kamihira-et-al\">R. Kamihira et al. (2022)<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/www.mdpi.com\/1420-3049\/27\/3\/1072\" target=\"_blank\" rel=\"noopener noreferrer\">Preparation and Application of a Chemical Probe for Identifying the Targets of the Marine Cyclic Peptide Kapakahine A<\/a><br \/>\nMolecules 2022, 27, 1072<\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/k-kobayashi-nakamura-et-al\">K. Kobayashi-Nakamura et al. (2022)<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0923181121003467\" target=\"_blank\" rel=\"noopener\">Rhamnazin suppresses melanosome transport by promoting the ubiquitin-mediated proteasomal degradation of melanophilin<\/a><br \/>\nJournal of Dermatological Science 105 (2022) 45\u201354<\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/hirata-et-al-2022\">Hirata et al.(2022)<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S266703132200077X\" target=\"_blank\" rel=\"noopener noreferrer\">Sirtuin inhibition and neurite outgrowth effect as new biological activities for Areca catechu nut alkaloids<\/a><br \/>\nPhytomedicine Plus 2 (2022) 100294<\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/bellail-et-al-2021\">Bellail et al.(2021)<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/www.science.org\/doi\/abs\/10.1126\/scitranslmed.abh1486\" target=\"_blank\" rel=\"noopener noreferrer\">Ubiquitination and degradation of SUMO1 by small-molecule degraders extends survival of mice with patient-derived tumors<\/a><br \/>\nSCIENCE TRANSLATIONAL MEDICINE 13 Oct 2021 Vol 13, Issue 615<\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/hamoya-et-al-2021\">Hamoya et al.(2021)<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32710739\/\" target=\"_blank\" rel=\"noopener noreferrer\">Artesunate inhibits intestinal tumorigenesis through inhibiting wnt signaling<\/a><br \/>\nCarcinogenesis, 2021, Vol. 42, No. 1, 148\u2013158<\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/ito-et-al-2021\">Ito et al.(2021)<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/www.cell.com\/cell-chemical-biology\/fulltext\/S2451-9456(21)00205-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2451945621002051%3Fshowall%3Dtrue\" target=\"_blank\" rel=\"noopener noreferrer\">Exploiting ubiquitin ligase cereblon as a target for small-molecule compounds in medicine and chemical biology<\/a><br \/>\nCell Chemical Biology 28, July 15, 2021<\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/dorman-et-al-2021\">Dorm\u00e1n et al.(2021)<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/B9780128210383000239#!\" target=\"_blank\" rel=\"noopener noreferrer\">Target identification and polypharmacology of nutraceuticals<\/a><br \/>\nNutraceuticals (Second Edition) Efficacy, Safety and Toxicity 2021, Pages 315-343<\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/miao-miao-zhao-et-al-2021\">Miao-Miao Zhao et al.(2021)<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34716337\/\" target=\"_blank\" rel=\"noopener noreferrer\">Berberine is an insulin secretagogue targeting the KCNH6 potassium channel<\/a><br \/>\nNATURE COMMUNICATIONS(2021) 12:5616<\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/watanabe-et-al-2021\">Watanabe et al.(2021)<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33652782\/\" target=\"_blank\" rel=\"noopener noreferrer\">Rabdosianone I, a Bitter Diterpene from an Oriental Herb, Suppresses Thymidylate Synthase Expression by Directly Binding to ANT2 and PHB2<\/a><br \/>\nCancers 2021, 13, 982<\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/y-kabe-et-al-6\">Y. Kabe et al. (2021)<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/www.mdpi.com\/2072-6694\/13\/13\/3265\" target=\"_blank\" rel=\"noopener\">Glycyrrhizin derivatives suppress cancer chemoresistance by inhibiting progesterone receptor membrane component 1<\/a><br \/>\nCancers, 13, 3265 (2021)<\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/nan-yagishita-kyo-et-al\">Nan Yagishita-Kyo et al. (2021)<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0006291X21003983\" target=\"_blank\" rel=\"noopener\">Testosterone interrupts binding of Neurexin and Neuroligin that are expressed in a highly socialized rodent, Octodon degus<\/a><br \/>\nBiochemical and Biophysical Research Communications 551 (2021) 54<\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/t-tsukahara-et-al\">T. Tsukahara et al. (2021)<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0898656821000395\" target=\"_blank\" rel=\"noopener\">Adenine nucleotide translocase 2, a putative target protein for 2-carba cyclic phosphatidic acid in microglial cells<\/a><br \/>\nCellular Signalling 82 (2021) 109951<\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/saito-et-al-2021\">Saito et al.(2021)<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/www.mdpi.com\/1420-3049\/26\/9\/2812\" target=\"_blank\" rel=\"noopener noreferrer\">\u03b1-Trifluoromethyl Chalcones as Potent Anticancer Agents for Androgen Receptor-Independent Prostate Cancer<\/a><br \/>\nMolecules 2021, 26, 2812<\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/takano-et-al-2020\">Takano et al.(2020)<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32093380\/\" target=\"_blank\" rel=\"noopener noreferrer\">The Surprising Effect of Phenformin on Cutaneous Darkening and Characterization of Its Underlying Mechanism by a Forward Chemical Genetics Approach<\/a><br \/>\nInt J Mol Sci. 2020 Feb 20;21(4):1451<\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/asatsuma-okumura-et-al-2020\">Asatsuma-Okumura et al.(2020)<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p>Molecular Mechanisms of the Teratogenic Effects of Thalidomide<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32414180\/\" target=\"_blank\" rel=\"noopener noreferrer\">Pharmaceuticals 2020, 13, 95; doi:10.3390\/ph13050095<\/a><\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/k-fujita-et-al\">K. Fujita et al. (2020)<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S026974912032889X?via%3Dihub\" target=\"_blank\" rel=\"noopener\">Pesticide treatment reduces hydrophobic pollutant contamination in Cucurbita pepo through competitive binding to major latex-like proteins<\/a><br \/>\nEnvironmental Pollution 266 (2020) 115179<\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/a-iwabuchi-et-al\">A. Iwabuchi et al. (2020)<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0176161719302238?via%3Dihub\" target=\"_blank\" rel=\"noopener\">Factors regulating the differential uptake of persistent organic pollutants in cucurbits and non-cucurbits<\/a><br \/>\nJournal of Plant Physiology 245 (2020) 153094<\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/t-saito-et-al\">T. Saito et al. (2020)<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0006291X19320315\" target=\"_blank\" rel=\"noopener\">Nobiletin and related polymethoxylated flavones bind to and inhibit the nuclear export factor Exportin-1 in NK leukemia cell line KHYG-1<\/a><br \/>\nBiochemical and Biophysical Research Communications 521 (2020) 457<\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/h-tsugawa-et-al\">H. Tsugawa et al. (2020)<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32991574\/\" target=\"_blank\" rel=\"noopener\">Short-chain fatty acids bind to apoptosisassociated speck-like protein to activate inflammasome complex to prevent Salmonella infection<\/a><br \/>\nPLoS Biol, 2020 18(9):e3000813<\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/j-cho-et-al-2\">J. Cho et al. (2020)<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32901087\/\" target=\"_blank\" rel=\"noopener\">L-Arginine prevents cereblon-mediated ubiquitination of glucokinase and stimulates glucose-6-phosphate production in pancreatic \u03b2-cells<\/a><br \/>\nCommunications Biology (2020) 3:497<\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/t-ito-et-al-2\">T. Ito et al. (2020)<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32522938\/\" target=\"_blank\" rel=\"noopener\">Molecular mechanisms of thalidomide and its derivatives<\/a><br \/>\nProc. Jpn. Acad., Ser. B 96 (2020)<\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/y-kabe-et-al-5\">Y. Kabe et al. (2020)<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/www.nature.com\/articles\/s41538-020-0064-6?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+npjscifood%2Frss%2Fcurrent+%28npj+Science+of+Food%29\" target=\"_blank\" rel=\"noopener\">Annexin A1 accounts for an anti-inflammatory binding target of sesamin metabolites<\/a><br \/>\nnpj Science of Food (2020) 4<\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/j-cho-et-al\">J. Cho et al. (2020)<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0006291X20309037\" target=\"_blank\" rel=\"noopener\">UGGT1 retains proinsulin in the endoplasmic reticulum in an arginine dependent manner<\/a><br \/>\nBiochemical and Biophysical Research Communications 527 (2020) 668<\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/t-furukawa-et-al\">T. Furukawa et al (2020)<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S2451945620303032\" target=\"_blank\" rel=\"noopener\">Dioctatin Activates ClpP to Degrade Mitochondrial Components and Inhibits Aflatoxin Production<\/a><br \/>\nCell Chemical Biology 27 (2020) 1396<\/p>\n\t\t<\/div>  \n\t<\/li>\n    <li>\n\t\t<p class=\"tit\"><a href=\"https:\/\/fgb.tamagawa-seiki.com\/english\/technology\/wu-et-al-2019\">Wu et al.(2019)<\/a><\/p>\n\t\t<div class=\"inner\">\n\t\t<p><a href=\"https:\/\/www.mdpi.com\/1420-3049\/24\/24\/4426\" target=\"_blank\" rel=\"noopener noreferrer\">Anti-Inflammatory and Anticancer Properties of Bioactive Compounds from Sesamum indicum L.\u2014A Review<\/a><br \/>\nMolecules 2019, 24, 4426<\/p>\n\t\t<\/div>  \n\t<\/li>\n          \n\n  <\/ul>\n\n<\/div>\n\t\t\n    <div class=\"tab-contents tab-txt01\">\n        \n  <\/ul>\n    \n    <\/div>\n  <\/div>\n<\/div>\n<\/section>\n\n","protected":false},"excerpt":{"rendered":"<p>Using the &#8220;chemical pull-down method,&#8221; which is a method for purifying target proteins using FG be [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":14,"menu_order":10,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"acf":[],"_links":{"self":[{"href":"https:\/\/fgb.tamagawa-seiki.com\/english\/wp-json\/wp\/v2\/pages\/16"}],"collection":[{"href":"https:\/\/fgb.tamagawa-seiki.com\/english\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/fgb.tamagawa-seiki.com\/english\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/fgb.tamagawa-seiki.com\/english\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/fgb.tamagawa-seiki.com\/english\/wp-json\/wp\/v2\/comments?post=16"}],"version-history":[{"count":21,"href":"https:\/\/fgb.tamagawa-seiki.com\/english\/wp-json\/wp\/v2\/pages\/16\/revisions"}],"predecessor-version":[{"id":1394,"href":"https:\/\/fgb.tamagawa-seiki.com\/english\/wp-json\/wp\/v2\/pages\/16\/revisions\/1394"}],"up":[{"embeddable":true,"href":"https:\/\/fgb.tamagawa-seiki.com\/english\/wp-json\/wp\/v2\/pages\/14"}],"wp:attachment":[{"href":"https:\/\/fgb.tamagawa-seiki.com\/english\/wp-json\/wp\/v2\/media?parent=16"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}